General Information

  • ID:  hor004495
  • Uniprot ID:  A0A6P6QZN2
  • Protein name:  Somatostatin-28
  • Gene name:  LOC113115527
  • Organism:  Carassius auratus (Goldfish)
  • Family:  Somatostatin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Carassius (genus), Cyprininae (subfamily), Cyprinidae (family), Cyprinoidei (suborder), Cypriniformes (order), Cypriniphysae (superorder), Otophysi, Ostariophysi (subcohort), Otomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SVESSNHLPARERKAGCKNFYWKGFTSC
  • Length:  28(93-120)
  • Propeptide:  MRLCELQCYLALLGLSLMLCGRSANSQLEPDLDFRHRRLMQRARAIGEATQDWTKKDVEEFLSLLSMPEMEMREADVSTAGENEDLRVELERSVESSNHLPARERKAGCKNFYWKGFTSC
  • Signal peptide:  MRLCELQCYLALLGLSLMLCGRSANS
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Somatostatin inhibits the release of somatotropin.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  17-28
  • Structure ID:  AF-A0A6P6QZN2-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor004495_AF2.pdbhor004495_ESM.pdb

Physical Information

Mass: 368535 Formula: C140H212N42O41S2
Absent amino acids: DIMQ Common amino acids: S
pI: 9.46 Basic residues: 6
Polar residues: 12 Hydrophobic residues: 7
Hydrophobicity: -86.43 Boman Index: -6905
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 31.43
Instability Index: 4833.93 Extinction Coefficient cystines: 7115
Absorbance 280nm: 263.52

Literature

  • PubMed ID:  8536941
  • Title:  Somatostatin-, Vasoactive Intestinal Peptide-, and Granulin-Like Peptides Isolated From Intestinal Extracts of Goldfish, Carassius Auratus